Osteoporosis Risk Screening
Bone metabolism and osteoporosis risk assessment including vitamin D and bone turnover markers, at our City of London clinic.
Osteoporosis Risk Screening
All-inclusive price
- Blood draw by registered nurse
- Comprehensive lab analysis
- Detailed results report
- Detailed nurse-written review
- Follow-up recommendations
Or call 020 7183 3709
Pay at the clinic on the day of your appointment
About This Screening
Osteoporosis Risk Screening
Osteoporosis is a progressive skeletal condition characterised by reduced bone mineral density and deterioration of bone microarchitecture, leading to increased fracture susceptibility. An estimated 3.5 million people in the UK have osteoporosis, with approximately 500,000 fragility fractures occurring annually. The condition develops silently over years and is frequently undiagnosed until a fracture occurs.
This screening panel measures serum biomarkers associated with bone metabolism, including calcium, phosphate, alkaline phosphatase, albumin, vitamin D (25-hydroxyvitamin D), and Crosslaps (a bone resorption marker). Together, these markers provide information about calcium balance, bone turnover rate, and the metabolic factors that influence bone mineralisation.
Key Highlights
- Assess vitamin D status (essential for calcium absorption)
- Evaluate calcium and phosphate balance
- Measure bone resorption with Crosslaps marker
- Identify deficiencies affecting bone mineralisation
- Results typically available within 4 working days
Vitamin D is essential for intestinal calcium absorption and plays a central role in bone health. Deficiency is highly prevalent in the UK due to limited sunlight exposure, particularly during autumn and winter months. Without adequate vitamin D, calcium absorption is impaired regardless of dietary intake, which can accelerate bone loss. Vitamin D deficiency is readily correctable with appropriate supplementation.
Crosslaps (serum CTx) is a bone resorption marker that reflects the rate of bone breakdown. Elevated levels indicate accelerated bone resorption, which, if sustained, leads to progressive bone density loss. This marker can also be used to monitor the effectiveness of anti-resorptive treatment in patients already receiving therapy for osteoporosis.
This screening is particularly relevant for post-menopausal women, men over 70, individuals with a family history of osteoporosis, those taking long-term corticosteroids, and anyone who has sustained a fracture from minimal trauma. It is important to note that this blood panel assesses factors affecting bone metabolism — it does not directly measure bone mineral density. DEXA scanning provides complementary information and may be indicated based on results.
What's Included
Comprehensive testing covering all essential biomarkers for a complete health picture.
Bone Health
- Alkaline Phosphatase
- Calcium
- Albumin
- Phosphate
- Crosslaps (Serum DPD)
- Vitamin D (25-OH)
Bone Health Assessment
Osteoporosis causes progressive reduction in bone mineral density, leading to fragility fractures from minimal trauma. It develops asymptomatically over years until fracture occurs. This panel assesses key factors affecting bone metabolism, assisting in risk identification before clinical sequelae develop.
Assess vitamin D status (essential for calcium absorption)
Evaluate calcium and phosphate balance
Measure bone resorption with Crosslaps marker
Identify deficiencies affecting bone mineralisation
Results typically available within 4 working days
Inform supplementation and lifestyle modification
Who Should Take This Test?
Post-Menopausal Women
Oestrogen withdrawal accelerates bone loss. Screening is particularly indicated in the post-menopausal period.
Men Over 70
While less prevalent than in women, male osteoporosis occurs, particularly in older age groups.
Established Risk Factors
Family history, low body mass index, smoking, excessive alcohol, prolonged corticosteroid use, or malabsorptive conditions increase risk.
Previous Fragility Fracture
A fracture from minimal trauma may indicate existing osteoporosis requiring investigation and management.
How to Prepare
Follow these steps before your appointment for the most accurate results.
Fasting is not strictly required, though we recommend avoiding calcium supplements for 24 hours before testing.
Continue taking prescribed medications unless specifically advised otherwise.
No special dietary preparation is needed.
Inform our team if you are currently taking osteoporosis medication (e.g. bisphosphonates), as this may affect bone marker interpretation.
Allow approximately 10–15 minutes for your appointment.
Ready to Take Control of Your Health?
Book your Osteoporosis Risk Screening today and get comprehensive insights into your health. Results available in 4 working days.
Frequently Asked Questions
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