Private Coeliac/Gluten Genetic Profile 2 Test in the City of London

Coeliac disease is an autoimmune condition where the immune system reacts to gluten, a protein found in wheat, barley, and rye. This immune reaction damages the lining of the small intestine and can impair nutrient absorption.

Coeliac disease affects approximately 1 in 100 people in the UK, though many cases remain undiagnosed. Blood tests that detect specific antibodies are the first step in investigating suspected coeliac disease.

What the Coeliac/Gluten Genetic Profile 2 Measures

• the Coeliac/Gluten Genetic Profile 2 test requires clinical history to be provided on the request form.
• Patient consent form is not required for this test.
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• If IgA deficiency is identified, a reflex deamidated Gliadin IgG will be carried out to determine whether the patient is likely to have coeliac disease.
• Coeliac pathway:
• Initial TTG IgA samples are received and tested
• If TTG IgA is LOW <0.2 U/ml reflex testing for Total IgA will be undertaken
• If Total IgA is LOW <0.1 g/L then reflex testing for deamidated Gliadin IgG test will be undertaken
• If TTG IgA is HIGH (>/= 10 U/ml) or in the equivocal range (7–10 U/ml) then reflex testing for Endomysial IgA will be undertaken as a confirmatory test for first time positive samples.

When This Test May Be Helpful

• Persistent digestive symptoms such as bloating, diarrhoea, or abdominal pain
• Unexplained iron deficiency anaemia
• Unexplained weight loss or fatigue
• A family history of coeliac disease
• Skin conditions such as dermatitis herpetiformis
• Unexplained nutrient deficiencies (e.g. folate, calcium, vitamin D)
• Screening in associated conditions (e.g. type 1 diabetes, autoimmune thyroid disease)

Understanding Your Results

Results are typically available within 10 days" and are delivered securely.

A positive tTG-IgA result suggests the presence of coeliac-related antibodies. However, coeliac disease cannot be diagnosed from a blood test alone — a gut biopsy is usually required to confirm the diagnosis.

Importantly, you must be eating gluten regularly at the time of the test (for at least 6 weeks) for the antibody test to be accurate. If you have already removed gluten from your diet, discuss this with your GP before testing.